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Updated: Jul 14, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
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Published on: August 29, 2015

タンパク質キナーゼCの主な基質の刺激に依存したミリスチロチル化

A A Aderem1, K A Albert, M M Keum

  • 1Rockefeller University, New York, New York 10021.

Nature
|March 24, 1988
PubMed
まとめ

バクテリアのリポポリサッカリド (LPS) は,タンパク質キナーゼC (PKC) 基板をミリスチル化することによって,マクロファージの反応を誘発する. このミリスチル化は,タンパク質を細胞膜に標的とし,LPS誘発の細胞信号伝達を媒介する可能性があります.

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