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Updated: Nov 18, 2025

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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SCF-RBR E3-E3スーパーアセンブリによるF-ボックスタンパク質へのウビキチン結合

Daniel Horn-Ghetko1, David T Krist1,2, J Rajan Prabu1

  • 1Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.

Nature
|February 4, 2021
PubMed
まとめ

クリン-RING (CRL) とRBR型リガゼによって形成されるE3リガゼスーパーアセンブリは,多様な基板の普遍化を可能にします. このメカニズムは,従来のE3リガゼのみシステムと互換性のない基板をubiquitylateするためにARIH1およびSCFリガスを利用します.

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