メタオーガニズムの訓練:微生物の対称性
Irah L King1, Maziar Divangahi2
1Meakins-Christie Laboratories, Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
Cell
|February 5, 2021
まとめ
感染症は免疫細胞と腸内微生物群を訓練し 将来の感染症に対する防御を強化します この訓練された免疫は 体の防衛機構を強化し より広範な抵抗力を提供します
科学分野:
- 免疫学
- 微生物学
- 感染症
背景:
- 生まれながらの免疫細胞は 感染や免疫によって再プログラムされ 記憶反応と 後の感染に対する広範な保護につながり 訓練された免疫として知られる現象です
- 訓練された免疫に寄与する共生微生物群の役割は,ほとんど未知のままです.
研究 の 目的:
- 免疫細胞に似た"訓練"プロセスにコンメンサルの微生物群が 受けられるかどうかを調べる.
- この微生物群の訓練が 関連のない感染症に対する耐性を高めるかどうかを判断する.
主な方法:
- この研究には,動物での感染の実験モデルが含まれる可能性が高い.
- 急性感染症後の共生微生物の組成と機能の変化の分析
- 二次性の異種病原体に対するコロニゼーション耐性の評価
主要な成果:
- 急性感染症は,共生微生物群を"訓練"することが示された.
- この微生物群の訓練により,異種感染症に対する植民抵抗性が向上した.
- この発見は,微生物群によって介在する宿主防御の新しく機制を示唆しています.
結論:
- コメンサル微生物群は 感染によって訓練され 後の異なる感染症に対する 強化された保護を提供することができます
- これは免疫細胞を超えて 微生物のコミュニティにまで広がる 訓練された免疫の新たな側面を表しています
- 微生物群の訓練を理解することで 感染症の予防や治療のための新しい戦略が生まれます
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