高強度インターバルトレーニング,適度な継続的なトレーニング,またはガイドラインに基づく身体活動アドバイスが,心不全の患者で保存されたエジェクション分数のピーク酸素消費に与える影響:ランダム化臨床試験
Stephan Mueller1,2, Ephraim B Winzer3, André Duvinage1,2
1Department of Prevention and Sports Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
JAMA
|February 9, 2021
まとめ
高強度インターバルトレーニングと中程度の連続トレーニングは,標準的な運動アドバイスと比較して,保存されたエジェクション分数 (HFpEF) の心不全患者のピーク酸素消費を有意に改善しませんでした.
科学分野:
- 心臓病科
- 運動 生理学
- 心不全 の 研究
背景:
- 耐久運動は,心不全でピーク酸素消費 (ピークV·o2) を改善し,エジェクション分数 (HFpEF) を保存する.
- HFpEFの最適な運動方法は不明である.
研究 の 目的:
- 高強度インターバルトレーニング (HIIT),中程度の連続トレーニング (MCT),およびガイドラインに基づく身体活動に関するアドバイスをHFpEF患者で比較する.
主な方法:
- 180人の静止状態のHFpEF患者は,HIIT,MCT,または対照群にランダムに12ヶ月間割り当てられました.
- 3ヶ月後のピークV·o2は主評価点であり,次要評価点には心肺機能の適性およびバイオマーカーが含まれていた.
- 介入は監視された 遠隔医療による 家庭での運動でした
主要な成果:
- HIITもMCTも3か12ヶ月の対照群と比較して,ピークV·o2の変化に統計的に有意な違いを示さなかった.
- 臨床的に重要な最小値である2.5 mL/ kg/ minのピークV·o2は,どのグループも達成できませんでした.
- 立体機能やナトリウレチンペプチドの有意な変化は認められなかった.
結論:
- HIITとMCTは,HFpEF患者におけるピークV·o2の改善に関して,ガイドラインに基づく身体活動に関する助言に比べて,有意な利点を提供していません.
- HFpEFに関する現在の運動推奨は,再評価が必要かもしれません.
- この集団に有効な運動介入を特定するにはさらなる研究が必要です.
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