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Updated: Nov 17, 2025

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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非リボソームペプチドの生物合成機能化

David L Niquille1, Ines B Folger1, Sophie Basler1

  • 1Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland.

Journal of the American Chemical Society
|February 11, 2021
PubMed
まとめ

タイロシジン合成酵素の単一の変異により,機能化されたフェニララニンの類型が非リボソームペプチド (NRP) に特異的に組み込まれる. これはNRPの効率的な光ラベル付けを可能にし,薬の発見と開発を助けます.

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