関連する実験動画

Updated: Nov 17, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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DRD1-Gs信号複合体のリガンド認識とアロステリック調節

Peng Xiao1, Wei Yan2, Lu Gou3

  • 1Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

Cell
|February 11, 2021
PubMed
まとめ

この研究は,ドーパミンD1受容体 (DRD1) とアゴニストおよび調節剤との相互作用の構造的基礎を明らかにしています. これらのメカニズムの理解は 神経学的および心血管疾患を標的とした新しい治療法の開発に不可欠です

キーワード:
DRD1-Gs複合体アロステリック調節カテコアミンccryo-EM についてドーパミン受容体ノンカテコール陽性アロステリックモジュール構造

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