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Updated: Nov 17, 2025

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
08:53

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency

Published on: September 15, 2021

3.0K

チチンの円形RNAは,SRSF10スプライシングに不可欠なバックスプライスモチーフを作成する

Anke J Tijsen1, Lucía Cócera Ortega1, Yolan J Reckman1

  • 1Amsterdam UMC, University of Amsterdam, Departments of Experimental Cardiology, Amsterdam Cardiovascular Sciences (A.J.T., L.C.O., Y.J.R., I.v.d.M., S.A., S.C.K., A.v.d.B., Y.M.P.), Amsterdam, The Netherlands.

Circulation
|February 15, 2021
PubMed
まとめ

TTN遺伝子から派生した円形RNA (circRNAs) は,鍵となる遺伝子のスプライシングを調節することにより,心臓筋機能に不可欠である. これらのTTN circRNAsの喪失は心臓の異常と収縮機能障害を引き起こす.

キーワード:
円形のRNA翻訳されていないRNAヒトのSRSF10タンパク質代替スプライシング心筋病誘導された多能幹細胞

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