ナトリウム減少による血圧効果:実験研究の投与量反応メタ解析
Tommaso Filippini1, Marcella Malavolti1, Paul K Whelton2
1Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy (T.F., M.M., M.V.).
Circulation
|February 15, 2021
まとめ
食中のナトリウム摂取は,血圧 (BP) の低下と線形的な関係があります. ナトリウム摂取量を減らすと,シストリック血圧とダイアストリック血圧の両方が低下し,ベースライン血圧が高い個体ではより大きな効果が得られます.
科学分野:
- 心血管の健康
- 栄養学
- 臨床試験
背景:
- 食中のナトリウム摂取は,血圧 (BP) と直接関連しています.
- 臨床試験の統計モデルに制限があるため,正確な用量反応の評価は困難でした.
- 以前の研究では関連性が見られたが,ナトリウム-BP曲線の正確な性質は不明であった.
研究 の 目的:
- 食事によるナトリウム摂取と血圧の関係を明らかにするために,用量反応メタ分析を行う.
- 複数の臨床試験のデータを分析するために新しい統計モデルを使用する.
- 異なる集団で異なるレベルのナトリウム摂取によるBP効果を調査する.
主な方法:
- 広範な文献調査により,食事によるナトリウム摂取量と血圧に関する適格な実験試験が特定されました.
- 1段階の立方脊髄混合効果モデルを使用して,投与量反応メタ解析を行った.
- 含めた試験には,少なくとも4週間の追跡調査,24時間尿中のナトリウム測定,および血圧モニタリングが必要でした.
主要な成果:
- 0. 4から7. 6g/ dのナトリウム摂取量に関する85件の試験を分析した.
- ナトリウム摂取と静脈動脈動脈動脈動脈の両方との間には,ほぼ線形的な関係が見られた.
- この関係は,ナトリウム曝露の全範囲で線形であり,低量または高量では平らにならなかった.
結論:
- 食事によるナトリウム摂取と血圧の低下は,摂取のあらゆるレベルにおいて線形的な関係がある.
- 低血圧はシストリック血圧とダイアストリック血圧の両方を効果的に低下させる.
- 血圧に対するナトリウムの有意な影響を強調した.
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