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Updated: Nov 17, 2025

A Model of Chronic Nutrient Infusion in the Rat
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過剰なO-GlcNAcylationは心臓不全と突然の死を引き起こす

Priya Umapathi1,2, Olurotimi O Mesubi1,2, Partha S Banerjee3

  • 1Division of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.

Circulation
|February 17, 2021
PubMed
まとめ

過剰なO-GlcNAcylationは,ミトコンドリアのエネルギーを損なうことで心不全を引き起こす. O-GlcNAcylationの減衰は心臓の改造に対して有益であり,心臓筋病に対する新しい治療戦略を提供することができる.

キーワード:
カムキイウリジンジホスファート N-アセチルグルコサミン心臓発作心不全高血圧ハイパートロフィー翻訳後のタンパク質処理

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