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Updated: Nov 17, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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Published on: April 9, 2018

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アポおよびペプチド結合形態におけるCGRP受容体の構造と動態

Tracy M Josephs1, Matthew J Belousoff1, Yi-Lynn Liang1

  • 1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.

Science (New York, N.Y.)
|February 19, 2021
PubMed
まとめ

この研究は,カルシトニン遺伝子関連ペプチド (CGRP) 受容体のアポおよびペプチド結合状態の冷凍EM構造を決定することによって,Gタンパク質結合受容体 (GPCR) 活性化の構造的基礎を明らかにし,クラスB1のGPCRメカニズムに関する洞察を提供します.

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