ヒトの腸内細菌菌の多様性の大規模な拡大
Luis F Camarillo-Guerrero1, Alexandre Almeida2, Guillermo Rangel-Pineros3
1Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
Cell
|February 19, 2021
まとめ
科学者はヒトの腸メタゲノムから 14万2000のウイルスゲノムを集めた Gut Phage Database を作成しました これは広範なウイルス多様性と遺伝子フローネットワークを明らかにし,将来のウイルス研究を改善します.
科学分野:
- 微生物学
- ウイルス学
- ゲノミクス
背景:
- バクテリオファージはバクテリアの進化と適応に不可欠です
- ヒトの腸内微生物群におけるウイルスの多様性と流行は十分に理解されていません.
研究 の 目的:
- ヒトの腸内の ウイルスの多様性を分類する
- ファグと宿主の相互作用と遺伝子フローを調査する.
- 腸内ウイルス研究のための包括的なリソースを確立する.
主な方法:
- 28,060人の腸のサンプルから 遺伝子データを採取した
- ウイルスのゲノム (10kb) を組み立て,再利用する.
- ホストの割り当てとウイルスクラスター (VCs) の遺伝分析.
主要な成果:
- 14万2000の非冗長なウイルスゲノムで Gut Phage Database を生成した.
- ウイルスの多様性が最も高いのは Firmicutes 属で
- ~36%のウイルスのクラスターは 細菌種間の遺伝子フローを容易にします
- 世界的に分布する280のVCと流行しているファグ群を発見した.
結論:
- ヒトの腸内には 広範囲で多様な 細菌菌群があります
- バクテリオファージはバクテリアの進化に影響を与える複雑な遺伝子フローネットワークを形成する.
- Gut Phage Databaseは,腸内ウイルスとファグの生態学を研究するための貴重なリソースです.
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