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Updated: Nov 16, 2025

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

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Published on: January 25, 2017

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IL-12とIL-23受容体共有の構造的基礎は,T対NK細胞の作用を形作るためのゲートウェイを明らかにする

Caleb R Glassman1, Yamuna Kalyani Mathiharan2, Kevin M Jude3

  • 1Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|February 19, 2021
PubMed
まとめ

研究者は,NK細胞を節約しながら,選択的にCD8+T細胞を活性化する新しいIL-12部分的アゴニストを設計しました. これらの標的治療は,毒性が低下した抗腫瘍免疫の有望性を示しています.

キーワード:
IL-12 についてIL-23 について免疫学について受容体生物学シグナリング構造生物学

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