男性と性交するアメリカ人における HIV 流行の持続と進化
Kenneth H Mayer1, LaRon Nelson2, Lisa Hightow-Weidman3
1Beth Israel Deaconess Medical Center, Harvard Medical School, Fenway Health, Boston, MA, USA.
Lancet (London, England)
|February 22, 2021
まとめ
米国で進行中のHIV流行は 生物学,個人,社会的要因によって引き起こされています. 多様なMSMサブグループがHIV感染を制御するために 文化的に適したプログラムが不可欠です
科学分野:
- 公衆衛生
- 流行病学
- 社会科学
背景:
- 米国では男性とセックスする男性 (MSM) がエイズと診断された最初の集団であり,HIV感染のリスクが高いままです.
- 社会生態学的観点では,この集団におけるHIVの流行に寄与する多面的な要因が強調されています.
研究 の 目的:
- アメリカ人のMSMの間で進行中のHIVの流行を促す要因を体系的に特定する.
- 多様なMSMのサブグループに対する 微妙で文化的に適したHIV予防とケア戦略の開発を促す.
主な方法:
- 社会生態学的枠組みを用いた体系的な文献検索
- MSMにおけるHIV感染と感染伝播の共通およびサブグループ特有の危険因子の分析
主要な成果:
- 重要な要因には,役割の汎用性,生物学的,個人的,社会的,構造的な要素が含まれます.
- マイノリティのMSMは,様々な混合,有害な生活経験,医療の回避により,集中したリスクに直面しています.
- 若いMSMは衝動制御とリスク議論の熟知に関連したリスクがあります.高齢のMSMは併発性に焦点を当てたケアを必要とします.トランスジェンダーのMSMはあまり研究されていませんが,リスクが高いです.
結論:
- 効果的なHIV対策には 共通の脆弱性に対処するプログラムを拡大し 特定の社会・文化・構造・行動問題に対応する 介入策を策定する必要があります
- 医療従事者の文化的な能力の訓練は,HIVのケアと予防の最適化,暴露前予防 (PrEP) と"検出不能は感染不能" (U=U) キャンペーンを活用するために不可欠です.
関連する概念動画
Sexually Transmitted Infections
570
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
570
Retrovirus Life Cycles
48.4K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
48.4K
Viral Mutations
37.3K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
37.3K
Immunodeficiency Diseases
1.5K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.5K
Pulmonary Tuberculosis I
494
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
494
Prevalence and Incidence
1.1K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.1K


