硫黄の封じ込めは,栄養の制限中に多細胞性を促進する
Beth Kelly1, Gustavo E Carrizo1, Joy Edwards-Hicks1
1Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany.
Nature
|February 25, 2021
まとめ
Dictyostelium discoideumの栄養素の制限は反応性酸素種を誘発し,グルタチオンにシステインを隔離する. この硫黄の調節により 増殖が止まり 多細胞の発達が可能になり 酸素と硫黄が活性化します
科学分野:
- 細胞生物学
- 生物化学
- 発達生物学
背景:
- Dictyostelium discoideumは栄養に依存する行動の変化を示し,飢餓時に単細胞から多細胞状態に切り替わります.
- この生物は,代謝が細胞の分化と機能にどのように影響するかを理解するためのモデルとして機能します.
研究 の 目的:
- 栄養素が限られたディクティオステリウム・ディスコイデウム (Dictyostelium discoideum) の活性酸素種 (ROS) の役割を調査する.
- 硫黄の代謝が栄養素の利用可能性に応じて細胞の運命を制御するメカニズムを解明する.
主な方法:
- 栄養素の制限下で反応性酸素種生成の分析
- グルタチオンのシステイン結合の定量化
- タンパク質変換と鉄硫黄クラスター酵素活性における硫黄利用の評価
主要な成果:
- 栄養素の制限はROSを誘導し,グルタチオンのシステイン結合につながります.
- この封じ込めはミトコンドリア代謝と細胞増殖のための硫黄の利用可能性を制限する.
- ROSによる硫黄の調節は,多細胞の発達を促進する非増殖状態を維持する.
結論:
- 反応性酸素種は 信号分子として作用し 硫黄の調節を通して 細胞の運命を決定します
- 酸素と硫黄は初期の真核生物の細胞運命を決定する 重要なシグナリング分子として識別される.
- この発見は,多細胞生物における栄養素の変動に対する細胞の反応を理解するための意味を持つ.
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