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Updated: Nov 16, 2025

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

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脂質シグナリングは,腫瘍におけるTreg細胞の機能的特化を強制する

Seon Ah Lim1, Jun Wei1, Thanh-Long M Nguyen1

  • 1Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.

Nature
|February 25, 2021
PubMed
まとめ

ステロール調節要素結合タンパク質 (SREBPs) を標的として,調節性T細胞における脂質合成を阻害すると,抗腫瘍免疫が生じます. このアプローチは癌の免疫療法を強化し 自己免疫的な問題を引き起こすことなく 新しい治療戦略を提供します

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