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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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骨の吸収が緑色になる

Jameel Iqbal1, Mone Zaidi2

  • 1Mount Sinai Bone Program, Center for Translational Medicine and Pharmacology, Department of Medicine and of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology, James J. Peters VA Medical Center, Bronx, NY 10463, USA.

Cell
|February 26, 2021
PubMed
まとめ
この要約は機械生成です。

骨を吸収する巨大な骨格細胞は 骨型細胞と呼ばれる小さな細胞に分解されます これらの骨型細胞は 異なる骨部位で新しい骨型細胞に再構成され 既存の科学的な理解に 異議を唱えます

さらに関連する動画

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
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A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

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Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow
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Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

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関連する実験動画

Last Updated: Nov 16, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
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Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow
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科学分野:

  • 細胞生物学
  • 骨の生物学
  • オステオクラスト生物学

背景:

  • オステオクラストは骨の再構築と再吸収に不可欠です.
  • 主流の理論では,骨細胞は骨の再吸収後にアポトーシスを受けると考えられていた.
  • オステオクラストの分化は,血液形成の前駆体からのみ発生すると考えられていた.

研究 の 目的:

  • 骨を再吸収した後の骨格細胞の運命を調査する.
  • オステオクラストの寿命と分化に関する 確立されたモデルに挑戦する
  • オステオクラストの行動と骨の再構築の代替メカニズムを探求する.

主な方法:

  • オステオクラストの行動を観察するためのインビボ画像技術.
  • オステオクラストの動態を 追跡する
  • 骨格細胞の形状と機能を分析する顕微鏡検査

主要な成果:

  • オステオクラストはアポトーシスを受けず,代わりにオステオモルフと呼ばれる小さな細胞に分裂します.
  • オステオモルフは新しい骨部位に 移動する能力があります
  • オステオモルフは,遠端部位で機能的な骨格状に再形成することができる.

結論:

  • オステオクラストは分断と再構成を含む,以前は認識されていないライフサイクルを示しています.
  • この発見は骨格細胞の分化とアポトーシスの教義に 異議を唱えるものです
  • この発見は,骨格再生における骨格細胞の動的かつ適応性の高い役割を示唆している.