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Updated: Nov 16, 2025

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
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Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

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In vivo CRISPRスクリーニングは,CD8+ T細胞の運命を決定する栄養信号処理を明らかにする

Hongling Huang1, Peipei Zhou1, Jun Wei1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cell
|February 26, 2021
PubMed
まとめ

Slc7a1とSlc38a2のような栄養素トランスポーターは,記憶T細胞 (TMEM) の分化を調節する. Pofut1は,T細胞の運命を栄養信号に結び付け,T細胞 (TEFF) の反応とTMEMの発達に影響を与える.

キーワード:
GDP-フコースノッチT細胞メモリ細胞サイクル終了免疫代謝in vivo プールされたCRISPRスクリーニングメタボリックの異質性栄養シグナリングシステム免疫学ターミナルエフェクターセル

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