子宮内膜症は慢性的な全身疾患である:臨床的な課題と新しいイノベーション
Hugh S Taylor1, Alexander M Kotlyar1, Valerie A Flores1
1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
Lancet (London, England)
|February 28, 2021
まとめ
子宮内膜症は全身の病気で 婦人科だけではありません 骨盤を超えて広範囲に及ぶ効果を認識することは,経口 GnRH 反抗剤のような新しい治療法を含む正確な診断と総合的な治療に不可欠です.
科学分野:
- 婦人科
- 内分泌学
- システム 疾患
背景:
- 子宮内膜症は世界全体の5〜10%の女性に影響しますが 診断が遅れて治療が長くなります
- 骨盤内膜症は 骨盤内膜症だけという 伝統的な考え方は 時代遅れです
- 現在では 子宮内膜症は 様々な症状を伴う全身疾患だと認識されています
研究 の 目的:
- 子宮内膜症を全身疾患として 最新の理解をレビューする.
- 古典的な婦人科の範囲を超えた症状を強調する.
- 診断と治療の進歩について
主な方法:
- 子宮内膜症に関する最新科学文献のレビュー
- 系統的効果と骨盤外症状に関する最近の発見の分析
- GnRHアンタゴニストを含む他の治療法の評価
主要な成果:
- 子宮内膜症は代謝に影響し 全身の炎症を引き起こし 脳内の遺伝子発現に影響し 痛みや気分障害を引き起こします
- この病気は生殖器を超えて 肝臓と脂肪組織に影響します
- プロゲステロン抵抗は,多くの患者の治療結果に影響します.
結論:
- 子宮内膜症は複雑な全身疾患であり,より広範な診断と治療方法が必要です.
- 口服用GnRHアンタゴニストのような新しい治療法は 副作用が少ない有効な代替剤です
- 子宮内膜症の全身的性質を認識することは 患者のケアと結果を改善する鍵です
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