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Updated: Nov 15, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

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リチウム・ビス・トリメチルシリルアミド (LiHMDS) によるサイクリック・ポリー ((α-ペプトイド) による環拡大ポリメリゼーション:生物活性脊髄への簡単なアクセス

Pedro Salas-Ambrosio1, Antoine Tronnet2,3, Marc Since4

  • 1Université Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, F-33600, Pessac, France.

Journal of the American Chemical Society
|March 2, 2021
PubMed
まとめ

研究者らは,環膨張ポリメリゼーションを用いたサイクルポリペプトイドの作成のための単純な方法を開発した. この画期的な発見により,Clostridioides difficile感染症に対する潜在的薬学的な応用を持つ新しい生物活性マクロサイクルの合成が可能になりました.

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