環境への侮辱の特徴
Annette Peters1, Tim S Nawrot2, Andrea A Baccarelli3
1Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, 81377 Munich, Germany; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Cell
|March 3, 2021
まとめ
環境への侮辱は様々な暴露によって 世界的な健康を害します この研究では 酸化ストレスやゲノム変異を含む 8つの重要な特徴を特定し これらの曝露が生涯にわたって 病気を引き起こす原因を説明しています
科学分野:
- 環境衛生科学
- 毒理学について
- 人間 の 健康
背景:
- 汚染された空気,水,土壌,食物から生じる環境への侮辱が,地球全体の健康に大きく影響しています.
- 幅広い化学物質やストレス要因への曝露は,職業,家庭,一般環境で発生します.
- 環境への曝露が害をもたらすメカニズムを理解することは,公衆衛生にとって極めて重要です.
研究 の 目的:
- 環境への曝露による健康への悪影響を理解するための統一的な枠組みを提案する.
- 生物学的プロセスや特徴を特定し,定義する. 環境への侮辱の病原性.
- 複雑な環境の混合が 深刻な健康被害を及ぼすことを説明します
主な方法:
- 既存の科学文献に基づいた概念的枠組みの開発
- 環境ストレス要因の影響を受ける 重要な生物学的経路の特定
- 特定の環境被曝と健康上の結果を関連付ける証拠のまとめ
主要な成果:
- 8つの提案された環境的侮辱の特徴:酸化ストレスと炎症,ゲノム変異と変異,表遺伝子変異,ミトコンドリア機能障害,内分泌障害,細胞間コミュニケーションの変化,微生物群の変化,神経系機能の障害.
- これらの特徴は,人間の生涯にわたる環境被曝の有害な影響を説明します.
- このフレームワークは,複雑な環境混合物の ほんの小さな濃度でさえ,深刻な健康への影響を 引き起こすことを明らかにするのに役立ちます.
結論:
- この8つの特徴は 環境に起因する病気の生物学的な基礎を理解するための包括的なモデルです
- この枠組みは,環境被曝の特定のメカニズムと累積的な影響に関する将来の研究を導くことができます.
- これらの特徴を認識することは,環境の健康上のリスクの世界的な負担を軽減するための効果的な戦略の開発に不可欠です.
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