MAP3K2 調節された腸ストロマ細胞は,固有の幹細胞ニッチを定義する
Ningbo Wu1,2, Hongxiang Sun1,2, Xiaoyun Zhao1,2
1Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nature
|March 4, 2021
まとめ
研究者らは,腸の修復に不可欠な新しいタイプの腸筋細胞,MAP3K2調節腸筋細胞 (MRISC) を特定しました. これらの細胞は,幹細胞機能をサポートし,損傷から保護するR-スポンディン1を産生します.
科学分野:
- 胃腸内科
- 幹細胞生物学
- 細胞 及び 分子 医学
背景:
- 腸内ストロマ細胞は腸内幹細胞 (ISC) の行動に影響するが,そのメカニズムは不明である.
- 組織ホメオスタシスと修復におけるストロマ細胞の役割を理解することは極めて重要です.
研究 の 目的:
- 腸の修復に関与する新しいストロマ細胞群を特定し,特徴づけること.
- ISCの維持と腸の再生を支えるストロマ細胞による分子メカニズムを解明する.
主な方法:
- 異なったストロマ細胞のサブセットを特定するためのトランスクリプトミックとエピジェネティック分析.
- 腸内損傷のマウスモデル
- ストロマ細胞機能とR-スポンディン1の産生を調節するシグナル伝達経路の分析
主要な成果:
- MAP3K2調節された腸内ストロマ細胞 (MRISCs) の発見,独特のストロマ細胞サブセット.
- MRISCはマウスの腸内損傷後のR-スポンディン1の主な原因です.
- MRISCはLGR5+ISCを維持し,R-スポンディン1の生成を促進するROS-MAP3K2-ERK5-KLF2軸を通じて損傷から保護する.
結論:
- MRISCは,WNTシグナリングを制御するISCニッチの重要な構成要素です.
- MRISCとそのシグナル伝達経路をターゲットにすることで,腸の損傷や疾患を治療する可能性がある.
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