レドックス活性抗生物質は,リンの生物利用性を高める

Darcy L McRose^1,2, Dianne K Newman^3,2

¹Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Science (New York, N.Y.)

|March 6, 2021

まとめ

微生物はリンが不足すると抗生物質を産生しますこれらの抗生物質は鉄鉱物を溶かして微生物の成長と栄養素の循環を促すことで微生物がリンにアクセスするのを助けます

科学分野:

環境微生物学
生地化学
抗菌剤耐性

背景:

微生物による抗生物質の生産は広く行われているが,その生態学的機能は十分に理解されていない.
は全ての生命にとって重要な栄養素でその存在が微生物の活動に影響します
リンの利用可能性は,しばしば酸化還元サイクルを通じて鉄鉱物によって調節されます.

研究の目的:

酸化還元活性抗生物質の生産とリン酸制限の関連を調査する.
フェナジン抗生物質の役割を探求する. 偽モンダによって生産される,の獲得.
フェナジンが環境における循環に寄与するかどうかを判断する.

主な方法:

フェナジン抗生物質の産生を,異なったの条件下で研究した.
酸化鉄の還元分解により,フェナジンがリンを溶解させる能力を評価した.
実験室とフィールドでの実験で,フェナジンがリンを限られた微生物の増殖に与える影響を評価した.

主要な成果:

フェナジンの抗生物質の産生は,フォスファーの利用によって大きく調節される.
フェナジンは,実験室とフィールドの両方で酸化鉄を減少させることで,リンを効果的に溶解することが示されました.
フェナジンの存在は,リンが限られた環境で微生物の増殖を促した.

結論:

レドックス活性抗生物質は,フェナジンによって示され,微生物のリン獲得において重要な役割を果たします.
これらの抗生物質は,鉄鉱物からの放出を促進することによって,循環に寄与します.
この発見は微生物の抗生物質の広範囲にわたる栄養素の循環における認識されていない生態学的機能を示唆している.

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