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Updated: Nov 14, 2025

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HDAC阻害は,既にある腹動機能不全を逆転させ,隠された細胞外マトリックス改造を阻害する

Joshua G Travers1,2, Sara A Wennersten1,2, Brisa Peña1,2

  • 1Department of Medicine, Division of Cardiology (J.G.T., S.A.W., B.P., R.A.B., Y.-H.L., K.M.D.-D., M.A.C., L.M., K.C.W., M.P.Y.L., T.A.M.), University of Colorado Anschutz Medical Campus, Aurora.

Circulation
|March 8, 2021
PubMed
まとめ

ヒストン脱酸化酵素 (HDAC) 阻害は,細胞外マトリックス膨張を阻害し,心臓の硬直を軽減することによって,確立された腹動機能 (DD) を逆転させました. この治療法は 保存されたエジェクション分子を用いて 心不全を治療する新しい戦略です

キーワード:
細胞外マトリックスフィブロブラスト繊維症ヒストンデセチラゼマススペクトロメトリー顕微鏡,原子力

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