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クルクソン・ディテルペンの総合成と標的の識別

Chengsen Cui1, Brendan G Dwyer2, Chang Liu1

  • 1Department of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.

Journal of the American Chemical Society
|March 11, 2021
PubMed
まとめ

研究者らはカルクソン・ディターペンの最初の完全合成を達成し,BRCA1関連ATM活性化剤1 (BRAT1) を主要な抗がん標的として特定した. カルクソンDはBRAT1を阻害し,DNA損傷反応と癌細胞の移動に影響を与えます.

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