関連する実験動画

Updated: Nov 14, 2025

The ChIP-exo Method: Identifying Protein-DNA Interactions with Near Base Pair Precision
09:27

The ChIP-exo Method: Identifying Protein-DNA Interactions with Near Base Pair Precision

Published on: December 23, 2016

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ヒトのメディエーター結合トランスクリプション前始動複合体の構造

R Abdella1,2, A Talyzina1,2, S Chen1,2

  • 1Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.

Science (New York, N.Y.)
|March 12, 2021
PubMed
まとめ

研究者は,ヒトのメディエーター・バインド・プレイニシエーション・コンプレックス (PIC) を,冷凍EMを用いて視覚化した. この構造は,メディエーターとCDK7が,真核転写に不可欠なRNAポリメラーゼIIC末端領域 (CTD) を結合し,リン酸化する相互作用を明らかにする.

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