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Updated: Nov 12, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

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DPP9はNLRP1のC端を隔離し,炎症体の活性化を抑制する

L Robert Hollingsworth1,2,3, Humayun Sharif1,2, Andrew R Griswold4,5

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

Nature
|March 18, 2021
PubMed
まとめ

ディペプチジルペプチダゼ8および9 (DPP8/DPP9) は,NLRP1炎症体のC端部と相互作用することでNLRP1炎症体の活性化を調節する. Val-boroProのような阻害剤は,この相互作用を妨害し,NLRP1の活性化と炎症反応を引き起こします.

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