高病原性ウイルスに対する共通の標的を持つ抗ウイルス薬
Lu Lu1, Shan Su1, Haitao Yang2
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
Cell
|March 19, 2021
まとめ
新しいウイルスは 絶え間ない脅威です RNA依存型RNAポリメラーゼのような保存されたウイルスタンパク質を標的とした広範囲の抗ウイルス薬の開発は,将来の疫病の準備に不可欠です.
科学分野:
- ウイルス学
- 薬物の発見
- 流行病学
背景:
- 新しく発生するウイルスは 歴史的に大きな死亡率を 引き起こしてきました
- 気候変動とグローバリゼーションは ウイルスの伝播を加速しています
- 保存されたウイルス標的に対する広範囲の抗ウイルス薬が必要である.
研究 の 目的:
- 共通の標的を持つ抗ウイルス薬の開発を見直す.
- 新しく発生し,再発生するウイルス脅威と戦うための戦略を特定する.
- 未来の抗ウイルス薬の開発に 洞察を提供するためです
主な方法:
- 抗ウイルス開発に関する文献レビュー
- 保存されたウイルスタンパク質を標的とした抗ウイルス薬の分析
- 共通のウイルス機能を標的とする抗ウイルス薬の検査
主要な成果:
- 異なるウイルスの保存されたタンパク質を標的とする抗ウイルス薬は有望である.
- RNA依存性RNAポリメラーゼを標的とする化合物は重要な焦点です.
- 共通の標的を持つ抗ウイルス薬の開発は 実行可能な戦略です
結論:
- 保存されたウイルスタンパク質を標的にすることは,広範囲の抗ウイルス活性に不可欠です.
- RNA依存性RNAポリメラーゼに対する抗ウイルス薬は,将来の流行に不可欠です.
- このレビューは,新興ウイルスに対する新しい抗ウイルス薬の開発のための基盤を提供します.
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