遺伝子コードの拡張: 開始,開発,商業化

Miglena Manandhar¹, Eugene Chun¹, Floyd E Romesberg¹

¹Synthorx, a Sanofi Company, La Jolla, California 92037, United States.

Journal of the American Chemical Society

|March 23, 2021

まとめ

遺伝子コード拡張 (GCE) により,治療効果が向上した新しいタンパク質が作られます. このレビューは,大腸菌におけるGCE,その商業化,および将来のタンパク質治療薬の可能性に焦点を当てています.

科学分野:

生物化学
分子生物学
バイオテクノロジー

背景:

タンパク質は20の標準のアミノ酸から合成されます
遺伝子コード拡張 (GCE) は,非正規のアミノ酸 (ncAAs) を組み込むことを可能にします.
これはタンパク質の機能と治療の可能性を拡大します

研究の目的:

GCEの過去と現在の状況を見直す
タンパク質治療のためのGCEの商用化を分析する.
学習した教訓と将来の方向性を話し合うために

主な方法:

E. coliにおけるGCEの方法論に焦点を当てた.
アカデミックと初期の商業化の取り組みのレビュー
GCEの実施における課題と成功の分析

主要な成果:

GCEは学術的な研究から商業的な応用へと移行しています
初期の商業化努力は貴重な教訓をもたらした.
*E. coli*はGCE発達の主要な宿主である.

結論:

GCEの方法論は急速に進歩しています
プロテイン治療のルーティン最適化は実現可能になっています
GCEは治療用タンパク質の開発に革命を起こそうとしています

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