Rambabu N Reddi1, Efrat Resnick1, Adi Rogel1

  • 1Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, 7610001, Israel.

まとめ

研究者らは,標的型共性阻害剤のための新種の電化分子であるα置換メタクリラミドを開発した. これらの化合物は調節可能な反応性を提供し,薬物発見と化学生物学のアプリケーションのための"オン"プローブを作成することができます.

関連する概念動画

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
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Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
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EDTA: Chemistry and Properties

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Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

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