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遺伝子工学による 骨髄細胞は 転移時に 免疫抑制プログラムを再バランスします

Sabina Kaczanowska1, Daniel W Beury1, Vishaka Gopalan2

  • 1Tumor Microenvironment and Metastasis Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

Cell
|March 25, 2021
PubMed
まとめ

IL-12を供給する遺伝子組み換え細胞で 骨髄細胞の免疫抑制をターゲットにすることで 腫瘍の負荷を軽減し,マウスの生存率を向上させる. このアプローチは転移した微小環境のバランスを取り戻し 新しいがん治療戦略を提供します

キーワード:
T細胞ガン免疫学遺伝子組み換え 骨髄細胞免疫抑制免疫療法インタールイキン 12転移した腫瘍の微小環境転移前のニッチ幹細胞のニッチ

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