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Updated: Nov 11, 2025

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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T細胞ホメオスタシスを維持し,自己免疫を防ぐためにmTORの活性化を抑制する

Ming Liu1,2,3, Jinyi Zhang1,2,3, Benjamin D Pinder1,2,4,5

  • 1Mount Sinai Hospital, Toronto, Ontario, Canada.

Science (New York, N.Y.)
|March 26, 2021
PubMed
まとめ

T細胞における機能不全のWAVE2タンパク質は,mTOR活性化を増加させることで重度の自己免疫を引き起こす. WAVE2機能の回復やmTORの抑制はT細胞の欠陥を修正し,自己免疫疾患を予防する.

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