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Updated: Nov 11, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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ニューロン強化剤はDNA単一鎖の断裂修復のためのホットスポットです

Wei Wu1, Sarah E Kargbo-Hill2, William J Nathan1,3

  • 1Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Nature
|March 26, 2021
PubMed
まとめ

ニューロンは特定のゲノム部位,特に増強剤で高レベルのDNA単一鎖断裂 (SSB) を蓄積する. これらの断片は 特定のメカニズムによって修復され 機能不全が 神経変性疾患の説明となるかもしれません

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