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Updated: Nov 11, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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複合天然産物の合成のためのディリゲントタンパク質ガイド・アシンメトリック・ヘテロカップリング

Stacie S Kim1, Elizabeth S Sattely2

  • 1Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States.

Journal of the American Chemical Society
|March 29, 2021
PubMed
まとめ

ディリゲントタンパク質とラッカゼは,コニフェリルアルコールのヘテロカップリングを誘導することにより,リグナンの同類物のエナント選択的合成を可能にします. この生物触媒的アプローチは 薬剤の潜在用途のための複雑な分子を 効率的に生み出します

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