銅 ((I) -触媒化されたラディカル-リレー反応 活性化されていないオレフィンの分子間1,2-アルキルボリレーションを可能にする
Sota Akiyama1, Natsuki Oyama1, Tsubura Endo1
1Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan.
Journal of the American Chemical Society
|March 30, 2021
まとめ
この研究は,アルキル電極を用いた非活性化オレフィンに対する最初の触媒的ラジカルリレーアルキルボリレーションを導入する. この方法は,アルキルとボリル群を二重結合に効率的に配置し,競合する置換反応を克服します.
科学分野:
- 有機化学
- カタリシス
- 合成方法論
背景:
- アルキルボリレーション反応は,オルガノボロン化合物の合成に不可欠である.
- 既存の方法はしばしば活性化されていないオレフィンと闘い,特定の基板を必要とします.
- ラジカル・リレーメカニズムは,C−C結合形成のための新しい経路を提供します.
研究 の 目的:
- 活性化されていないオレフィンの最初の触媒的分子間1,2-アルキルボリレーションを開発する.
- アルキル電子とビスコラトジボロンを含む 根源リレーメカニズムを使用する.
- オレフィン二重結合の領域選択的機能化を実現する.
主な方法:
- 分子間アルキルボリレーションのための触媒システムを使用する.
- 反応を容易にするために 根源リレーメカニズムを利用する.
- 競争するボリル置換を克服し,要求の高いアルキル電極を使用します.
主要な成果:
- 活性化されていないオレフィンの触媒的分子間1,2-アルキルボリレーションが成功しました.
- C=C二重結合にアルキルとボリル群の地域選択的導入
- 多様なアルキル基 (ジェム・ディフローロ,モノフローロ,三次性,二次性) の導入が実証されている.
結論:
- この研究は,オレフィンの1,2-非機能化のための新しい合成経路を確立しています.
- ラジカルリレーアプローチはアルキルボリレーションの強力な戦略を提供します.
- この方法は,様々なアルキル機能の設置に広く適用できます.
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