柔軟なスケーリングと社会的な声のコミュニケーションの持続性

Jingyi Chen^1,2, Jeffrey E Markowitz³, Varoth Lilascharoen⁴

¹Department of Neuroscience, Scripps Research, La Jolla, CA, USA.

Nature

|April 1, 2021

まとめ

マウスは社会的なコミュニケーションのために超音波発声 (USV) を柔軟にスケールします側視前領域 (LPOA) のニューロンが関与する新しい回路は,USVの強度と持続時間を制御して,周水管灰色 (PAG) を無抑制します.

科学分野:

神経科学
動物の行動
コミュニケーション

背景:

声は種間の社会的なコミュニケーションに重要な役割を果たします
ネズミでは,求愛超音波発声 (USV) は雌の香りに触発されます.
柔軟な発声スケーリングと神経制御のメカニズムは不明です.

研究の目的:

ネズミの柔軟な発声スケーリングの基礎にある神経回路を調査する.
超音波発声 (USV) の振幅と持続時間を制御する特定のニューロンと経路を特定する.
社会的文脈が発音のパラメータにどのように影響するか理解する.

主な方法:

エストロゲン受容体1 (ESR1) を発現する側視前領域 (LPOA) の神経細胞の光遺伝的活性化.
ネズミの脳における神経追跡と機能記録
異なる刺激条件下での超音波発声 (USV) パラメータ (振幅,持続時間) の分析.

主要な成果:

LPOA ESR1ニューロンの活性化が求愛USVの完全なレパートリーを誘発する.
消毒回路モチーフ:LPOAニューロンは局所的なペリアクエドゥクトアルグレー (PAG) 内ニューロンを阻害し,USVゲートニューロンを放出する.
LPOAのアクティベーションはUSVの幅を拡大し,阻害の回復が遅れてUSV発作が長くなり,柔軟な制御が示される.

結論:

LPOA-PAG解禁経路はUSVの音量と発作の持続時間に対する柔軟な制御を可能にします.
この回路モチーフはネズミの適応性のある声の社会的コミュニケーションに極めて重要です
発見は哺乳類の声の柔軟性の神経的な基礎に洞察を与えます

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