社会的関わりを抑制する 桃体回路
Jeong-Tae Kwon1,2, Changhyeon Ryu1,2, Hyeseung Lee1,2,3
1Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nature
|April 1, 2021
まとめ
研究者たちは ネズミの神経経路を発見し 不健康なメスとの交配を抑制しました これは社会リスクの評価に不可欠な,後部中部皮質の桃体 (COApm) とチロトロピン放出ホルモン (TRH) を関わります.
科学分野:
- 神経科学
- 行動生物学
- 動物 の 行動
背景:
- 交尾のような生まれつきの社会的な行動は 重要なものですが リスクもあります
- 危険な社会的相互作用を評価し抑制する 神経機構は十分に理解されていません
研究 の 目的:
- 不健康なメスとの交配を抑制する 神経回路を特定する
- 社会的リスクの評価における特定の脳領域と神経調節体の役割を明らかにする.
主な方法:
- アナトミック・トレーシングとマウスの機能的イメージング
- サーキットレベルのエピスタティック分析
- 神経活動と受容体の機能の操作
主要な成果:
- 皮質の杏仁核 (COApm) は,不健康なメスとの交配を抑制するために重要です.
- この抑制は,チロトロピン放出ホルモン (TRH) を通じて,中枢桃体 (MEA) へのCOApm投射によって行われます.
- MEAにおけるTRHシグナリングは,メスの健康状態に基づいて交尾行動を調節する.
結論:
- COApm,MEA,TRHを含む新しい神経経路は,健康状態に基づいて社会的相互作用を調節します.
- このメカニズムは 個人が社会的コストと利益のバランスをとって 病気の拡散を防ぐことを可能にします
- 配偶者選びの欠陥は 健康に重大な影響を及ぼします
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