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Updated: Nov 10, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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臨時回復は,エピジェネティックリモデリングを通じて,枯渇したCAR-T細胞の機能を回復します

Evan W Weber1, Kevin R Parker2, Elena Sotillo1

  • 1Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|April 2, 2021
PubMed
まとめ

休息しているキメリック抗原受容体 (CAR) -T細胞は,がん免疫療法における重要な障壁である疲労を逆転させることができます. このアプローチは抗腫瘍機能を回復し,CAR-T細胞の有効性を高め,疲労が永続的であるという考えに異議を唱えます.

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