関連する実験動画

Updated: Nov 10, 2025

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

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設計されたタンパク質は,抗体をモジュラーなナノケージに組み立てる

Robby Divine1,2, Ha V Dang1, George Ueda1,2

  • 1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Science (New York, N.Y.)
|April 2, 2021
PubMed
まとめ

抗体ナノケージの計算設計は,治療的な抗体活性を強化します. これらの新しい構造は,細胞表面受容体のシグナル伝達を改善し,SARS-CoV-2擬似ウイルスの中和を増加させます.

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Protein Complex Assembly02:41

Protein Complex Assembly

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Antibody Structure01:10

Antibody Structure

Overview
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Antibody Structure and Classes01:25

Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
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Globular Proteins01:27

Globular Proteins

In organisms, proteins are the most abundant macromolecules. They act as the building blocks of life and play various crucial roles in the body. Proteins can be broadly classified into two distinct subtypes based on their shape and solubilities: globular proteins and fibrous proteins.
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Protein Complexes with Interchangeable Parts

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Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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