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Updated: Nov 9, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

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CARは小腸におけるT細胞の胆酸への適応を誘導する

Mei Lan Chen1,2, Xiangsheng Huang3, Hongtao Wang3

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.

Nature
|April 8, 2021
PubMed
まとめ

核受容体CARは,MDR1の発現を調節することにより,小腸の免疫細胞を胆酸の毒性から保護する. この発見は,クローン病と関連する小腸炎症の治療に新しい戦略を提供します.

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