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Updated: Nov 9, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Published on: November 5, 2019

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2,658 人の癌ゲノムにおける腫瘍内遺伝的異質性の特徴

Stefan C Dentro1, Ignaty Leshchiner2, Kerstin Haase3

  • 1Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK; Big Data Institute, University of Oxford, Oxford OX3 7LF, UK.

Cell
|April 8, 2021
PubMed
まとめ

腫瘍内異質性 (ITH) が治療抵抗性を引き起こす. この研究では 38の癌の全ゲノム配列を 2,658個分析し 腫瘍の進化を理解する上で 重要なサブクローン拡張と ドライバー変異を明らかにしました

キーワード:
枝分かれする進化癌を誘発する遺伝子癌の進化腫瘍内異質性パンガンゲノミクスサブクローン再構築腫瘍フィロゲニー全ゲノムシーケンシング

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