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Updated: Nov 9, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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核酸救済因子DNPH1を標的にすることで,BRCA欠乏細胞をPARP阻害剤に敏感にする

Kasper Fugger1, Ilirjana Bajrami2, Mariana Silva Dos Santos2

  • 1The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. stephen.west@crick.ac.uk kasper.fugger@crick.ac.uk.

Science (New York, N.Y.)
|April 9, 2021
PubMed
まとめ

DNPH1をターゲットにすることで,BRCA欠乏症の患者のがん治療が改善されます. DNPH1を阻害すると,PARP阻害剤 (PARPi) に対する感受性が高まり,細胞毒性ヌクレオチド濃度が上昇し,癌細胞死につながる.

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