TOP1阻害療法では,SARS-CoV-2による致死性炎症から保護されます
Jessica Sook Yuin Ho1, Bobo Wing-Yee Mok2, Laura Campisi1
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell
|April 9, 2021
まとめ
トポイソメラーゼ1 (TOP1) 阻害は,SARS-CoV-2感染によって引き起こされる致死性炎症を効果的に抑制します. トポテカン (TPT) という薬を用いたこのアプローチは,重度のCOVID-19の治療と死亡率の低減に有望であることを示しています.
科学分野:
- ウイルス学
- 免疫学
- 薬理学について
背景:
- 深刻な急性呼吸器症候群のコロナウイルス2型 (SARS-CoV-2) パンデミックは,世界的な健康に影響を及ぼしています.
- 炎症性サイトカインの上昇は,COVID-19の重症度および死亡率の増加と相関しています.
研究 の 目的:
- SARS-CoV-2による炎症におけるトポイソメラーゼ1 (TOP1) の役割を調査する.
- 重度のCOVID-19の潜在的宿主指向療法としてTOP1阻害を評価する.
主な方法:
- エピジェネティック,トランスクリプション,インビトロ,インビボの研究を含む多次元分析.
- 動物モデルでのTOP1阻害剤であるトポテカン (TPT) による治療
主要な成果:
- TOP1阻害はSARS-CoV-2による致死性炎症を著しく抑制する.
- TPT治療はハムスターとマウスのモデルで,感染後4日後に投与された場合でも,罹患率を低下させ,死亡率を回復させた.
結論:
- TOP1抑制は,重度のSARS-CoV-2感染に対する有望な宿主指向の治療戦略を表しています.
- COVID-19に対するTPTおよびその誘導体の再利用は,その利用可能性と低コストのため,臨床試験を正当化しています.
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