高密度リポプロテイン 抗炎症能力とインシデント心血管疾患
Congzhuo Jia1,2, Josephine L C Anderson1, Eke G Gruppen3,4
1Department of Pediatrics (C.J., J.L.C.A., U.J.F.T.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Circulation
|April 12, 2021
まとめ
高密度脂質 (HDL) の抗炎症能力の低下は,心血管疾患の増加と関連しています. このHDL機能を測定することで,従来の要因を超えて心臓血管疾患のリスク予測が改善されます.
科学分野:
- 心血管科学
- 脂質代謝
- 炎症の生物学
背景:
- 高密度脂質 (HDL) 機能は,心血管疾患 (CVD) の新興要因である.
- この研究では,HDLの抗炎症能力と一般集団における最初のCVDの間の潜在的な関連性を調査しています.
研究 の 目的:
- HDLの抗炎症能力が心臓血管事件を予測するかどうかを調査する.
- HDLの抗炎症能力がHDLのコレステロールとコレステロール流出能力から独立しているかどうかを判断する.
- HDLの抗炎症能力が既存のCVDリスク予測モデルを強化するかどうかを評価する.
主な方法:
- PREVEND研究における ネストケース・コントロールの設計
- TNFα誘発のVCAM- 1mRNAの発現をインビトロで測定したHDLの抗炎症能力.
- 最初のCVDイベントの369例は369例の対照群と一致し,平均10. 5年間追跡された.
主要な成果:
- HDLの抗炎症能力は,対照群と比較して有意に低かった (P< 0. 001).
- HDLの抗炎症能力の低下は,CVDの発生率と逆相関していた (OR per 1 SD,0. 74; P=0. 002).
- HDLの抗炎症能力は,フレーミングハムリスクスコアの予測能力を改善しました (P=0. 002).
結論:
- HDLの抗炎症能力は,一般集団における心血管疾患の発生に逆相関する.
- この関連性は,HDLコレステロールとコレステロール流出能力とは無関係です.
- HDLの抗炎症能力をリスクスコアに含めると,心血管疾患の予測が向上します.
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