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Updated: Nov 8, 2025

Covalent Labeling with Diethylpyrocarbonate for Studying Protein Higher-Order Structure by Mass Spectrometry
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タンパク質バイオ分子によるディアジリンのラベリングの好み

Alexander V West1, Giovanni Muncipinto2, Hung-Yi Wu1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|April 20, 2021
PubMed
まとめ

ダイアジリンを用いたフォトアフィニティラベリング (PAL) は,その反応性を理解することで改善される. アルキルディアジリンは酸性アミノ酸と膜タンパク質を標識し,アリルディアジリンはカルベンを介して反応し,実験設計に役立ちます.

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