心血管疾患に対する新たなグローバルなアプローチへの呼びかけ

Gemma A Figtree¹, Keith Broadfoot², Barbara Casadei^3,4,5

¹Kolling Institute, Royal North Shore Hospital, University of Sydney, Australia (G.A.F.).

Circulation

|April 20, 2021

まとめ

心血管新生療法の開発には薬の発見と患者の階層化における革新が必要です先進的な分子と画像技術への投資は心血管疾患の標的治療の開発を加速させることができます

科学分野:

心血管医学
薬剤療法
薬物の発見

背景:

冠動脈疾患,心不全,高血圧などの主要な心血管疾患の薬剤療法には大きなギャップがあります.
現在の薬の開発経路は長く高価で成功率は低いため高い疾患負担にもかかわらず産業の投資を阻害しています

研究の目的:

心血管疾患の新たな治療方法への継続的な投資の必要性を強調する.
薬の発見,患者層分化,臨床翻訳の改善の機会を探求する.

主な方法:

生物学的メカニズムに基づいた分層化のための改善された画像と分子マーカーを通じて,先進的な患者フェノタイプ化を活用します.
新しい病気のメカニズムを明らかにするために偏りのない"オミック"アプローチを使用します
薬剤発見のための先進的なプラットフォームと,より適切な臨床前モデルを有効性および毒性研究に使用する.

主要な成果:

患者の階層化の改善により,高通量分子技術によって開発された標的型療法が可能になります.
偏見のない"オミック"アプローチは,新しい心血管疾患のメカニズムを発見する可能性を秘めています.
薬剤開発プラットフォームと臨床前モデルの進歩は治療の開発を向上させることができます

結論:

薬の開発パイプラインを発見から導入まで再考することは心血管研究と投資の活性化に極めて重要です
心血管疾患の治療開発の全域にわたる革新的なプラットフォームとアプローチが必要です

キーワード:

動脈硬化症心血管系薬物の発見薬物療法心不全オーガノイド精密医療治療薬

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