COVID-19の急性後遺症の高次元の特徴づけ
Ziyad Al-Aly1,2,3,4,5, Yan Xie6,7,8, Benjamin Bowe6,7,8
1Clinical Epidemiology Center, Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, USA. zalaly@gmail.com.
Nature
|April 22, 2021
まとめ
長期COVIDは生存者に影響を及ぼし,急性期を超えて重大な健康損失を引き起こします. これには呼吸器系の問題,神経疾患,精神疾患,複数の臓器系に影響を与える医療使用量の増加が含まれます.
科学分野:
- 感染症
- 公衆衛生
- 臨床医学
背景:
- 急性COVID-19の症状は知られているが,長期的な健康上の影響 (後遺症) は十分に理解されていない.
- COVID-19の急性後遺症を理解することは,患者の回復と医療制度の計画管理に不可欠です.
研究 の 目的:
- 生存者のCOVID-19診断から6ヶ月後に発生する健康状態,薬剤使用,検査異常を体系的に特定し,記述する.
- 急性COVID-19の重症度と急性後遺症の発生リスクとの関係を分析する.
主な方法:
- 米国退役軍人省の 医療データベースを活用して 総合的な分析を行いました
- COVID-19生存者 (診断後≥30日) の診断,薬物使用,検査異常を特定するために,高次元のアプローチを採用した.
- 複数の臓器システムと治療薬の使用における発生後遺症の評価,急性感染症の重症度との相関関係 (非入院,入院,ICU).
主要な成果:
- COVID-19の生存者は,診断後30日以上の死亡リスクと医療資源の利用率が高くなります.
- 呼吸器,神経系,神経認知,精神的健康,代謝,心血管,胃腸疾患を含む 幅広い後遺症を特定しました
- 痛み止め,抗うつ薬,抗不安薬,抗高血圧薬,口服低血糖薬の使用が増加し, 臓器系における検査異常も認められた.
- 初期COVID-19感染の重症度とともに増加する,後遺症の明確なリスクグラデーションを示した.
結論:
- COVID-19の生存者は,急性疾患を超えて,肺および肺外の健康損失の大きな負担を経験します.
- 発見は,COVID-19 以後の慢性的な健康損失を軽減するために,積極的な保健システム計画と多学科ケア戦略の必要性を強調しています.
- この研究は,継続的な研究と患者支援を必要とする,COVID-19の長期的,多系統的影響を強調しています.
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