米国におけるSARS-CoV-2変種B.1.1.7の早期導入と感染
Tara Alpert1, Anderson F Brito1, Erica Lasek-Nesselquist2
1Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Cell
|April 23, 2021
まとめ
英国で最初に発見されたSARS-CoV-2 B.1.1.7型は,アメリカ全土に急速に広がった. この高度に伝染性の高いCOVID-19変種に対する公衆衛生の対応には,強化されたゲノム監視が不可欠です.
科学分野:
- 流行病学について
- ゲノム 監視
- 公衆衛生
背景:
- イギリスで確認されたSARS-CoV-2 B.1.1.7系は,伝染性の向上により,世界的な健康リスクをもたらしています.
- 2020年12月以降,米国でB.1.1.7の症例が2,500件以上記録されており,その感染範囲は不明である.
研究 の 目的:
- 米国内のSARS-CoV-2 B.1.1.7変種の主な侵入点と確立パターンを特定する.
- B.1.1.7系統の将来的な支配を 予測する
主な方法:
- 統合された旅行,ゲノム,診断データの分析.
- B.1.1.7の発生と州間拡散を追跡する
- 変数の優位性を予測するモデルです.
主要な成果:
- ニューヨーク,カリフォルニア,フロリダはB.1.1.7の主要な米国入国点として特定されました.
- 2020年12月上旬に複数の独立したB.1.1.7施設が存在し,その後州間感染が確認された.
- B.1.1.7が3月までに多くの州で支配的な系統になると予測されています.
結論:
- B.1.1.7を含むSARS-CoV-2変種に対するゲノム監視の緊急強化が必要である.
- 改善された監視により,新たなウイルス系に対する公衆衛生戦略と対応がより良くなるでしょう.
- B.1.1.7の急速な拡散と確立は,ウイルスの進化の継続的なモニタリングの必要性を強調しています.
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