糖尿病の発症時の年齢と後の認知症のリスクとの関連

Claudio Barbiellini Amidei^1,2, Aurore Fayosse¹, Julien Dumurgier^1,3

¹Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, Inserm U1153, Paris, France.

JAMA

|April 27, 2021

まとめ

2型糖尿病の早期発症は認知症のリスクを大幅に高めます 2型糖尿病と診断される年齢が小さいほど認知症のリスクが高くなります

科学分野:

神経科学
内分泌学
流行病学

背景:

2型糖尿病の罹患率は増加しており,近年では早期発症が観察されています.
血管系の合併症は知られていますが,早期発症の2型糖尿病と認知症のリスクとの関連は完全に理解されていません.

研究の目的:

2型糖尿病の発症年齢の低さと認知症の発生率との関連を調査する.
早期に診断された2型糖尿病が後に認知症を発症するリスクと相関するかどうかを判断する.

主な方法:

イギリスのホワイトホールII前向きコホート研究 (1985年−2019年) のデータを活用した.
電子医療記録を通して 2型糖尿病の診断と発症した認知症の追跡を実施しました
糖尿病の発症時の年齢と認知症リスクの関係を評価するために,多変量調整分析と線形傾向テストを使用しました.

主要な成果:

2型糖尿病の発症時の若さと認知症のリスクの増加との間に有意な分類された関連性が見られた.
70歳より10年以上前に発症した糖尿病の参加者は,認知症のリスクが2. 12倍に増加しました.
2型糖尿病の発症時の年齢の5年減が,70歳で認知症のリスクの1. 24倍増加と関連していた.

結論:

2型糖尿病の発症時の年齢が低いと,後に認知症になるリスクが高くなります.
これらの発見は,認知症のリスクを軽減するために早期の糖尿病管理の重要性を強調しています.

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