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Updated: Nov 7, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
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Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Published on: June 10, 2021

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アジンのC-Hフローラルキル化のためのリン媒介型sp2−sp3結合

Xuan Zhang1, Kyle G Nottingham1, Chirag Patel1

  • 1Department of Chemistry, Colorado State University, Fort Collins, CO, USA.

Nature
|April 28, 2021
PubMed
まとめ

新しいフッ素アルキルフォスフィンは,薬物分子における直接的なC−H結合変換を可能にします. この方法は,薬剤開発に不可欠なピリジンにトリフルオロメチル (CF3) と二フルオロメチル (CF2H) の導入を容易にする.

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Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
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