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Updated: Nov 7, 2025

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PIK3CAとCCMの変異は,癌のようなメカニズムを通して洞窟細胞に燃料を与えます

Aileen A Ren1, Daniel A Snellings2, Yourong S Su3

  • 1Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.

Nature
|April 28, 2021
PubMed
まとめ

PI3K- mTOR経路の活性化とCCM複合体の喪失により,脳の洞穴異常 (CCM) が増加します. ラパミシンのようなmTORC1阻害剤は,CCMの形成を阻害し,攻撃的な血管異常を治療する可能性がある.

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